2011 Fiscal Year Final Research Report
Development of Noble Structure PI Polyamide Recognizing to a Unique Sequence on double-strand DNA
| Project/Area Number |
22790301
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | PIポリアミド / 固相合成法 / ユニーク型PIポリアミド / ポリアミドブロック |
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| Research Abstract |
Cross form PI polyamide having 0alaninelPy or p-alanine/lm was succeeded in making into a target all DNA sequence without GGGG and CCCC. Then, for the synthesis of long chain PI polyamide recognizing 12 base-pair DNA sequence, 2-3 mer PI polyamide blocks by solid phase synthesis using HMPB resin was developed and the long chain PI polyamide could be synthesized elongating these PI polyamide blocks. And it was established that solid phase synthesis of the cyclic PI polyamides more strong DNA binding than hair-pin PI polyamide.
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[Journal Article] Transcriptional in hibition of hypertrophicscars by a gene silencer pyrroleimidazole polyamide targeted to the TGF-b 1 promoter2011
Author(s)
Matsuda Y, Fukuda N, Ueno T, Katakawa M, Wang X, Watanabe T, Matsui S, Aoyama T, Saito K, Banda T, Matsumoto Y, Nagase H, Matsumoto K, Sugiyama H.
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Journal Title
Kidney International
Volume: 79(1)
Pages: 46-56
Peer Reviewed
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[Journal Article] Inhibition of MMP-g transcription and suppression of tumor metastasis by pyrroleimidazole polyamide2010
Author(s)
Wang X, Nagase H, Watanabe T, Nobusue H, Suzuki T, Asami Y, Shinojima Y, Kawashima H, Takagi K, Mishra R, Igarashi J, Kimura M, Takayama T, Fukuda N, Sugiyama H.
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Journal Title
Cancer Science
Volume: 101(3)
Pages: A-N4
Peer Reviewed
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