2011 Fiscal Year Final Research Report
Role of selectin-carbohydrate interactions in rolling of cells in blood vessels of the brain
| Project/Area Number |
22790303
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Nagoya University (2011)
National Center for Geriatrics and Gerontology (2010) |
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Principal Investigator |
UCHIMURA Kenji 名古屋大学, 医学系研究科, 特任准教授 (20450835)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 細胞・組織 / 生体分子 / 糖鎖 / 脳・神経 |
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| Research Abstract |
It has been reported that bone marrow derived cells extravasate into the brain of Alzheimer model mice. Molecular interactions between selectins and their carbohydrate ligands are the first step of leukocyte infiltration into tissues through the blood. Here, we investigated possible involvement of selectins and their ligands in diapedesis of bone marrow derived cells into Alzheimer brain. We have detected cell surface expression of sialyl Lewis X, a ligand of selectins, ina mouse bone marrow cell line. We also found that expression of one of selectins was up-regulated in brain vasculature of aged Alzheimer model mice. We have shown that the selectin ligand was involved in rolling and adhesion of bone marrow cells in the brain of Alzheimer model mice. These results indicated that selectin-carbohydrate ligandinteraction might be important for extravasation of bone marrow derived cells into Alzheimer brain.
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[Journal Article] Expression of long-form N-acetylglucosamine-6- O-sulfotransferase 1 in human high endothelial venules2012
Author(s)
Fujiwara, M., Kobayashi, M., Hoshino, H., Uchimura, K., Nakada, T., Masumoto, J., Sakai, Y., Fukuda, M., Nakayama, J
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Journal Title
J. Histochem. Cytochem
Volume: 60
Pages: 397-407
Peer Reviewed
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[Journal Article] Heparan sulfate subdomains that are degraded by Sulf accumulate in cerebral amyloid β plaques of Alzheimer's disease: evidence from mouse models and patients2012
Author(s)
Hosono-Fukao, T., Ohtake-Niimi, S., Hoshino, H., Britschgi, M., Akatsu, H., Hossain, M. M., Nishitsuji, K., van Kuppevelt, T. H., Kimata, K., Michikawa, M. Wyss-Coray, T., and Uchimura, K.
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Journal Title
Am. J. Pathol
Volume: 180
Pages: 2056-2067
Peer Reviewed
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[Journal Article] RB4CD12 epitope expression and heparan sulfate disaccharide composition in brain vasculature2011
Author(s)
Hosono-Fukao, T., Ohtake-Niimi, S., Nishitsuji, K., Hossain, M. M., van Kuppevelt, T. H., Michikawa, M. and Uchimura, K.
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Journal Title
J. Neurosci. Res
Volume: 89
Pages: 1840-1848
Peer Reviewed
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