2011 Fiscal Year Final Research Report
Myostatin regulate the glycolysis in muscle
| Project/Area Number |
22790328
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Fujita Health University |
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Principal Investigator |
NAKATANI Masashi 藤田保健衛生大学, 総合医科学研究所, 助教 (00421264)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 分子病態学 |
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| Research Abstract |
Myostatin is a potent negative regulator of skeletal muscle growth. In this study, we found that the muscle in myostatin knockout mice changed any metabolic associated factors. In addition we crossed myostatin knockout mice with mdx mice, a model for Duchenne muscular dystrophy. The muscle in crossed mice was showed hypertrophy and hyperplasia, but the ratio of regenerating muscle fiber was nearly identical to mdx mice. Improvement of muscular dystrophy was considered hypertrophy and hyperplasia of increased muscle.
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