2011 Fiscal Year Final Research Report
The effects of sex steroid hormones on human pulmonary fibrosis
| Project/Area Number |
22790337
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Tohoku University |
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Principal Investigator |
MIKI Yasuhiro 東北大学, 大学院・歯学研究科, 助教 (50451521)
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| Research Collaborator |
ABE Keiko 埼玉医科大学, 医学部, 講師 (80455782)
SUZUKI Takashi 東北大学, 大学院・医学系研究科, 教授 (10261629)
SASANO Hironobu 東北大学, 大学院・医学系研究科, 教授 (50187142)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 肺線維症 / 間質性肺炎 / エストロゲン / aromatase |
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| Research Abstract |
This is the first study to demonstrate tissue concentration of estrogen in human interstitial pneumonia (IP)/lung fibrosis tissues. Results from this study suggest that estradiol concentration in IP tissue is increased by aromatase, which is located in alveolar epithelial cells. In the result of mice model, expression level of phosphodiesterase mRNA in lung tissue was increased through the androgen signal. These results all suggest that sex steroid hormones, estrogen and androgen may play an important role in the development of IP.
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[Journal Article] Intratumoral localization of aromatase and interaction between stromal and parenchymal cells in the non-small cell lung carcinoma microenvironment2010
Author(s)
Yasuhiro Miki, Takashi Suzuki, Keiko Abe, Satoshi Suzuki, Hiromichi Niikawa, Shinya Iida, Shuko Hata, Jun-ichi Akahira, Kazushige Mori, Dean B. Evans, Takashi Kondo, Hisafumi Yamada-Okabe, Hironobu Sasano
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Journal Title
Cancer Res
Volume: 70(16)
Pages: 6659-6669
Peer Reviewed
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[Presentation] 間質性肺炎におけるエストロゲン受容体とアロマターゼの発現2011
Author(s)
谷内真司, 鈴木貴, 三木康宏, 阿部佳子, 藤島史喜, 中村保宏, 佐藤聡子, 笠島敦子, 石田和之, 渡邊みか, 笹野公伸
Organizer
第100回日本病理学会総会
Place of Presentation
横浜市
Year and Date
2011-04-29
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