2012 Fiscal Year Final Research Report
Biological implication and clinical application for novel thyroid cancer specific biomarker
| Project/Area Number |
22790350
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Tokai University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 甲状腺乳頭癌 |
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| Research Abstract |
Immunohistochemical analysis with an SNX5-specific mAb established in this study consistently demonstrated the preferential expression of SNX5 in Papillary thyroid carcinoma cell. More interestingly, epithelial cells expressing excess SNX5 showed high levels of Caspase-2. Collectively further investigations focusing on the unique modality of SNX5 could clarify its unidentified mechanism and improve our understanding of the tumor cell biology of thyroid gland malignancies
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[Journal Article] Sorting nexin 5 of a new diagnostic marker of papillary thyroid carcinoma regulates Caspase-22012
Author(s)
Ara S, Kikuchi T, Matsumiya H, Kojima T, Kubo T, Ye RC, Sato A, Kon S, Honma T, Asakura K, Hasegawa T, Himi T, Sato N, Ichimiya S
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Journal Title
Cancer Sci
Volume: 103(7)
Pages: 1356-62
DOI
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