2011 Fiscal Year Final Research Report
Partial tandem duplication in childhood acute myeloblastic leukemia and molecular targeted therapy
| Project/Area Number |
22790355
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 病理学 / 癌 / 遺伝子 / 白血病 |
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| Research Abstract |
We established a suppression system of MLL partial tandem duplication(MLL-PTD) gene using siRNA in childhood acute myeloblastic leulkemia cell line with MLL-PTD, KOPM-88. The siRNA repressed the growth of KOPM-88 cells by 20%. Furthermore, we confirmed anti-tumor effect of anti-CD26 monoclonal antibody against CD26 positive malignant hematopoietic tumor cell lines.
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