2012 Fiscal Year Final Research Report
Analysis of lymphatic metastasis in early gastrointestinal carcinoma
| Project/Area Number |
22790360
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Toho University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 消化器 |
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| Research Abstract |
Using early colorectal carcinoma cases,histopathological observations and immunohistochemistry for LYVE-1, von Willebrand factor, MMP-7, CXCL12, and ANGPTL4 were conducted. Relationships between LN metastasis and growth pattern, status of muscularis mucosae, depth of cancer invasion, histopathological type, tumour budding, neutrophil infiltration in cancer cells (NIC), fibrotic cancer-stroma type, Crohn’s-like lymphoid reaction, microscopic abscess formation, lymphatic invasion, the expression of MMP-7, CXCL12 and ANGPTL4 in cancer cells at the invasive front were determined. By multivariate analysis,lymphatic invasion, NIC, and MMP-7 expression at the invasive front were independent predictors of LN metastasis.
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Research Products
(3 results)
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[Journal Article] Histopathological predictors of regional lymph node metastasis at the invasive front in early colorectal cancer.2011
Author(s)
Akishima-Fukasawa Y, Ishikawa Y, Akasaka Y, Uzuki M, Inomata N, Yokoo T, Ishii R, Shimokawa R, Mukai K, Kiguchi H, Suzuki K, Fujiwara M, Ogata K, Niino H, Sugiura H, Ichinose A, Kuroda Y, Kuroda D, Ishii T.
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Journal Title
Histopathology.
Volume: 59(3)
Pages: 470-481
DOI
Peer Reviewed
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[Presentation] 早期結腸癌におけるリンパ節転移の組織学的規定因子.2010
Author(s)
深澤 由里, 石川 由起雄, 赤坂 喜清, 宇月 美和, 下川 伶子, 向井 清, 木口 英子, 藤原 美恵子, 鈴木 高祐, 一瀬 晃洋, 緒方 謙太郎, 新野 史, 杉浦 仁, 石井壽晴.
Organizer
第99回日本病理学総会.
Place of Presentation
東京
Year and Date
20100400
