2012 Fiscal Year Final Research Report
Analysis of CTGF,the new candidate of the tumor suppressor gene in ovarian cancer, for personalized anti-cancer therapy
| Project/Area Number |
22790364
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | National Defense Medical College |
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Principal Investigator |
KIKUCHI Ryoko 防衛医科大学校, 医学教育部医学科専門課程, 助教 (80535063)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 分子病理 / 卵巣癌 |
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| Research Abstract |
Knockdown of CTGF with specific small interfering RNAs in OVISE cells, the ovarian clear cell carcinoma cell line, and in OVSAHO cells, the ovarian serous carcinoma cell line enhanced resistance to apoptosis on exposure to paclitaxel, but not enhanced resistance to apotosis on exposure to carboplatin, cisplatin and doxorubicin.
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