2011 Fiscal Year Final Research Report
Alteration of cancer and microenvironment in serosal invasion area
| Project/Area Number |
22790365
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East |
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Principal Investigator |
KOJIMA Motohiro 独立行政法人国立がん研究センター, 臨床開発センター, 室長 (30338470)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 病理学 / 癌 |
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| Research Abstract |
We showed that tumor invasion beyond the peritoneal elastic lamina(elastic laminal invasion : ELI) is strong prognostic factor which influence on the stratification pT factor in TNM classification. We found that fibrosis and tumor budding are histological features of ELI. To know biological feature of the fibroblast in serosal area, we established primary culture of fibroblast from serosal and submucosal area of human sigmoid colon. From the result of co-injection of fibroblast and colon cancer cells, we demonstrate that fibroblast from serosal area actively promote cancer growth and metastasis.
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