2011 Fiscal Year Final Research Report
Induction of tumor-specific cytotoxic T cells mediated by cross presentation on dendritic cells
| Project/Area Number |
22790370
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 腫瘍免疫 / 樹状細胞 / クロスプレゼンテーション / CTL / IL-6 / IFN-γ / ニューロキニン / 神経ペプチド |
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| Research Abstract |
Mechanism for cross-presentation of tumor antigen was elucidated in the induction of tumor-antigen specific killer T cells by the antigen-loaded DCs in tumor bearing mice. IL-6, a major cytokine produced under tumor-bearing state, significantly reduced antigen-presenting ability by DCs. Neuropeptide signaling through Neurokinin-2 receptor(NK2R) was closely related with the function of DCs in Type 1 immune responses. In the near future, development of effective generation of tumor-antigen specific T cells by regulation of DC function would be a promising strategy for cancer immunotherapy
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[Journal Article] Toll-like receptor-dependent IL-12 production by dendritic cells is required for activation of natural killer cell-mediated Type-1 immunity induced by Chrysanthemum Coronarium L2011
Author(s)
Tanaka S, Koizumi SI, Masuko K, Makiuchi N, Aoyagi Y, Quivy E, Mitamura R, Kano T, Ohkuri T, Wakita D, Chamoto K, Kitamura H, Nishimura T
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Journal Title
Int Immunopharmacol
Volume: 11(2)
Pages: 226-32
URL
Peer Reviewed
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[Journal Article] The extract of Japanese soybean, Kurosengoku activates the production of IL-12 and IFN-γby DC or NK1. 1(+) cells in a TLR4-and TLR2-dependent manner2011
Author(s)
Tanaka S, Koizumi S, Makiuchi N, Aoyagi Y, Quivy E, Mitamura R, Kano T, Wakita D, Chamoto K, Kitamura H, Nishimura T
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Journal Title
Cell Immunol
Volume: 266(2)
Pages: 135-42
URL
Peer Reviewed
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