2011 Fiscal Year Final Research Report
Development of a novel technique for myoblast transplantation that is capable of preventing life-threatening arrhythmias and of dramatically restoring cardiac contractility
| Project/Area Number |
22790373
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 再生医学 / 心筋 |
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| Research Abstract |
We have succeeded in developing a novel technique for cardiac regeneration that excels other methods both in efficacy and in safety. Conventional myoblast transplantation, one of the most promising myocardial reconstructive approaches ever,was plagued by life-threatening arrhythmias and inadequate contractile restoration. Our studies suggest that these problems are simultaneously conquered by transducing myoblasts with protein X prior to implantation. This holds promise for yet earlier realization of a revolutionary heart regenerative therapy with much better prognosis than ever before.
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