2011 Fiscal Year Final Research Report
Roles of THG-1 on cellular proliferation, differentiation and tumorgenesis
| Project/Area Number |
22790374
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Experimental pathology
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 扁平上皮がん / THG-1 / EGF |
|---|
| Research Abstract |
THG-1/Tsc22D4 belongs to Tsc-22 family members. However, biological and physiological roles of THG-1 remain unclear. We found that THG-1 is localized in basal layer of normal squamous epithelium, and overexpressed in squamous cell carcinomas. Knockdown of THG-1 in tumor cells suppresses cell proliferation, invasiveness and tumorigenicity. Moreover, overexpression of THG-1 suppresses the differentiation in squamous epithelium formation. We also found that THG-1 is phosphorylated by Ras-ERK pathway, which is required for the promotion of cellular proliferation by EGF and Ras-mediated tumorigenesis. Furthermore, we found an oncogenic mutation of THG-1 in tumors. These findings highlight the importance of THG-1 as a novel oncogene of squamous cell carcinomas.
|
Research Products
(11 results)
