2011 Fiscal Year Final Research Report
Development of mouse model of neuromyelitis optica induced by aquaporin-4 protein immunization
| Project/Area Number |
22790375
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Chiba University |
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Principal Investigator |
UZAWA Akiyuki 千葉大学, 医学部・附属病院, 医員 (10533317)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 疾患モデル動物 |
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| Research Abstract |
To reveal the pathogenesis of neuromyelitis optica, we tried to develop mouse model of neuromyelitis optica induced by aquaporin-4 (AQP4) protein immunization. Although serum anti-AQP4 antibody titers were increased by the immunization with AQP4 protein, mice did not exhibit any symptoms and no inflammatory cell were observed in the central nervous system because of the presence of blood-brain barrier. When anti-AQP4 antibody was administered to the infant mice that were vulnerable BBB, inflammatory cells infiltrated in the periventricular spaces, leading that anti-AQP4 antibody itself may have pathogenicity.
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