Anti-virus protection by p53 inducible factor

2011 Fiscal Year Final Research Report

• Project/Area Number: 22790387
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Experimental pathology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: SHIN-YA Masaharu 京都府立医科大学, 医学部, プロジェクト研究員 (10405277)
• Project Period (FY): 2010 – 2011
• Keywords: P53

Research Abstract

p53 is a important for tumor suppressor gene, while it's contribution of anti-virus protection remains unclear. We found that p53 induced Fbw7βworked to anti-virus protection. Although three isoforms existed in Fbw7, it was shown that Fbw7βstrongly acts on anti-virus protection. These present results may lead to development of a novel antiviral drug.

Research Products

• [Journal Article] Interleukin-28B(IL-28B) acts synergistically with cisplatin to suppress the growth of head and neck squamous cell carcinoma (2011)
  • Author(s): Yoshimoto K, T. Kishida, H. Nakano, M. Matsui, M. Shin-Ya, T. Shimada, S. Nakai, J. Imanishi, M. Takeuchi, Y. Hisa & O. Mazda
  • Journal Title: J Immunother Volume: 34(2) Pages: 139-48
  • Peer Reviewed
• [Journal Article] MDR1a/lb gene silencing enhances drug sensitivity in rat fibroblast-like synoviocytes (2010)
  • Author(s): Honjo K, KA. Takahashi, 0.Mazda, T. Kishida, M. Shinya, D. Tokunaga, Y. Arai, A. Inoue, N. Hiraoka, J. Imanishi & T. Kubo
  • Journal Title: J Gene Med Volume: 12(2) Pages: 219-27
  • Peer Reviewed
• [Journal Article] Early-stage blocking of Notch signaling inhibits the depletion of goblet cells in dextran sodium sulfate-induced colitis in mice (2010)
  • Author(s): Shinoda M, M. Shin-Ya, Y. Naito, T. Kishida, R. Ito, N. Suzuki, H. Yasuda, J. Sakagami, J. Imanishi, K. Kataoka, O. Mazda & Yoshikawa T.
  • Journal Title: J Gastroenterol Volume: 45(6) Pages: 608-17
  • Peer Reviewed
• [Presentation] Gain-of-function and loss of function analyses in vivo of transcriptional factor and cytokine genes using Epstein唯err virus傭ased episomal vectors, and their implication to novel strategies of gene therapy and regenerative medicine (2010)
  • Author(s): Kishida T, Nakai N, Matsui M, Yoshimoto K, Nakano H, Shin-Ya M, Shimada T, Nakai S, Hisa Y, Katoh N, Mazda O.
  • Organizer: 2010 International Symposium on Micro-Nano Mechatronics and Human Science
  • Place of Presentation: Nagoya
  • Year and Date: 20101108-09