2011 Fiscal Year Final Research Report
Chemokines as novel therapeutic targets in inflammatory arthritis
| Project/Area Number |
22790388
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Tohoku University |
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Principal Investigator |
INUI Masanori 東北大学, 加齢医学研究所, 講師 (80443985)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 炎症 / 骨破壊 |
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| Research Abstract |
In this study, we examined the physiological roles of C-C chemokines in antigen-induced arthritis and osteoclast development. MIP-1α-CCR1 signaling enhanced inflammatory bone destruction and osteoclast development. Thus, CCL3-CCR1 signaling might be a molecular target for the treatment of inflammatory arthritis.
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