2011 Fiscal Year Final Research Report
The host RNA uptake related gene in Schistosoma japonicum
| Project/Area Number |
22790393
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KUMAGAI Takashi 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (40369054)
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| Co-Investigator(Renkei-kenkyūsha) |
OHTA Nobuo 東京医科歯科大学, 医歯学総合研究科, 教授 (10143611)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 蠕虫 / RNAi / 住血吸虫 / sid-1 |
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| Research Abstract |
Schistosomes induce the RNA interference(RNAi) using long dsRNA in soaking method, such as C. elegans. It is previously reported that schistosomes incorporate the dsRNA, including host derived RNA. To understand the relationships between RNA uptake and parasitism, sid-1 gene, related to RNAi machinery, was investigated. The mRNA of sid-1 was increased in the larval stage after the invasion to the host, and was regulated by the induction of long dsRNA. However, the schistosomes knocked down with sid-1 siRNA, were not effects to RNAi machinery, dsRNA uptake, and parasitism in the host. These mean that schistosomes may have the distinct RNAi machinery.
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Research Products
(19 results)
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[Journal Article] Phylogenetic relationships ofrat lungworm, Angiostrongylus cantonensis, isolated from different geographical regions revealed widespread multiple lineages2012
Author(s)
Tokiwa T, Harunari T, Tanikawa T, Komatsu N, Koizumi N, Tung KC, Suzuki J, Kadosaka T, Takada N, Kumagai T, Akao N, Ohta N
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Journal Title
Parasitol Int
Volume: (in press)
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[Journal Article] Cerebral Schistosomiasis Due to Schistosoma haematobium Confirmed by PCR Analysis of Brain Specimen2011
Author(s)
Imai K, Koibuchi T, Kumagai T, Maeda T, Osada Y, Ohta N, Koga M, Nakamura H, Miura T, Iwamoto A, Fujii T
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Journal Title
J Clin Microbiol
Volume: 49
Pages: 3703-6
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[Journal Article] Plasmodium falciparum isolates from southern Ghana exhibit polymorphisms in the SERCA-type PfATPase6 though sensitive to artesunate in vitro2011
Author(s)
Kwansa-Bentum B, Ayi I, Suzuki T, Otchere J, Kumagai T, Anyan WK, Osei JH, Asahi H, Ofori MF, Akao N, Wilson MD, Boakye DA, Ohta N.
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Journal Title
Malar J
Volume: 11
Pages: 10 : 187
Peer Reviewed
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[Journal Article] Administrative practices of health professionals and use of artesunate-amodiaquine by community members for treating uncomplicated malaria in southern Ghana : implications for artemisinin-based combination therapy deployment2011
Author(s)
Kwansa-Bentum B, Ayi I, Suzuki T, Otchere J, Kumagai T, Anyan WK, Asahi H, Akao N, Wilson MD, Boakye DA, Ohta N
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Journal Title
Trop Med Int Health
Volume: 10
Pages: 134-139
Peer Reviewed
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[Journal Article] Schistosomicidal and antifecundity effects of oral treatment of synthetic endoperoxide N-892011
Author(s)
Taniguchi T, Kumagai T, Shimogawara R, Ichinose S, Hiramoto A, Sato A, Morita M, Nojima M, Kim HS, Wataya Y, Ohta N.
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Journal Title
Parasitol Int
Volume: 60
Pages: 231-6
Peer Reviewed
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[Journal Article] Schistosome eggs have a direct role in the induction of basophils capable of a high level of IL-4 production : Comparative study of single-and bisexual infection of Schistosoma mansoni in vivo2010
Author(s)
Anyan KW, Kumagai T, Shimogawara FR, Seki T, Akao N, Obata K, Bentum KB, Bosompen MK, Boakye AD, Wilson DM, Karasuyama H, Ohta N
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Journal Title
Tropical Medicine and Health
Volume: 38
Pages: 13-22
Peer Reviewed
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