2011 Fiscal Year Final Research Report
Regulatory gene expression by cohesin in malaria parasite
| Project/Area Number |
22790397
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | マラリア / エピジェネティック / インスレーター |
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| Research Abstract |
The new evidence is emerging suggesting that the cohesin complex is involved in the regulation of gene expression in yeast and mammals. However, a precise role for the cohesion complex in the regulation of gene expression remains completely unexplored in malaria parasite. Thus we cloned cohesin from malaria parasite and generated the cohesin-tagged transgenic parasite to assess the cohesin distribution in the genome. Cohesin mapping would reveal the gene expression mechanism of different developmental stages between mammalian host and mosquito of malaria parasite.
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