2011 Fiscal Year Final Research Report
Analysis of human cell death mechanism caused by ADP-ribosyltransferase Cholix toxin
| Project/Area Number |
22790401
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Chiba University |
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Principal Investigator |
YAHIRO Kinnosuke 千葉大学, 大学院・医学研究院, 特任准教授 (80345024)
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| Co-Investigator(Renkei-kenkyūsha) |
OGURA Kohei 千葉大学, 大学院・医学研究院, 特任研究員 (00586612)
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| Project Period (FY) |
2010 – 2011
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| Keywords | ADP-リボシル化毒素 / アポトーシス |
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| Research Abstract |
Cholix toxin (Cholix) is a novel ADP-ribosyl transferase cytotoxin produced by Vibrio cholerae. Cell death pathway induced by eEF2-ADP-ribosylation differs in various cell types. Cholix-induced apoptosis in HeLa cells is dependent on caspase activation, which is regulated by both mitochondria-dependent and -independent pathways. In conclusion, inflammatory caspases and caspase-8 were responsible for both mitochondrial signals and other caspase activation.
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