2011 Fiscal Year Final Research Report
Basic research of an antifungal agent targeting to checkpoint kinases
| Project/Area Number |
22790411
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Iwate Medical University |
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Principal Investigator |
TSUDA Kayoko 岩手医科大学, 薬学部, 助教 (30444524)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 病原性 |
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| Research Abstract |
Aiming to find new antifungal agents, this study focused on CaMps1p, an essential protein kinase in Candida albicans causing deep microsis. Through our in vitro screening, LY83583 was found to block kinase activity of CaMps1p but not human ortholog hMps1p. Specific effect of LY83583 resulted in growth inhibition of C. albicans. This study not only revealed a new antifungal agent but also led to find another target of LY83583, a well-known inhibitor of guanylate cyclase.
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