2011 Fiscal Year Final Research Report
Analysis of the mechanism of Salmonella-induced colitis.
| Project/Area Number |
22790415
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | サルモネラ / 腸炎 / III型分泌機構 |
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| Research Abstract |
Salmonella enterica serovar Typhimurium causes acute gastroenteritis. This bacterium has three Type III secretion systems(SPI-1, SPI-2 and flagella), which are required for intestinal inflammation. In this study, we tried to identify effectors secreted into host cells through T3SS-2.Unfortunately, we could not identify the SPI-2 effector associated with acute intestinal inflammation in a streptomycin pretreated mouse model. However, we showed that SpvC, both SPI-1 and SPI-2 T3SS effector, evades the immune response in the intestinal mucosa in the early stage of infection and facilitates bacterial dissemination at late stages of infection.
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[Journal Article] Comparative proteomic analysis of Salmonella enterica serovar Typhimurium ppGpp-deficient mutant to identify a novel virulence protein required for intracellular survival in macrophages2010
Author(s)
Haneda T, Sugimoto M, Yoshida-Ohta Y, Kodera Y, Oh-Ishi M, Maeda T, Shimizu-Izumi S, Miki T, Kumagai Y, Danbara H, Okada N
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Journal Title
BMC Microbiol
Volume: 10
Pages: 324
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