2011 Fiscal Year Final Research Report
Development of a new nasal vaccine effective against many types of influenza that based on pulmonary surfactant
| Project/Area Number |
22790433
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Virology
|
|---|
| Research Institution | The University of Tokushima |
|---|
Principal Investigator |
MIZUNO Dai 徳島大学, 疾患酵素学研究センター, 助教 (70380061)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | 感染防御 / ワクチン / 肺サーファクタント |
|---|
| Research Abstract |
We developed a new vaccine, which was constitute of influeza M2 angigen and SF10 a synthetic adjuvant that mimics pulmonary surfactant. Fluoresceinated M2 delivery to cultured dendritic cells was significantly enhanced by co-administration of SF10. And intranasal immunization of M2-SF10 enhanced local and systemic immune responses, compared with those induced by M2 antigen alone.
|
