2011 Fiscal Year Final Research Report
Visualization of influenza virus progeny vRNP complex and analysis of cytoplasmic machineries responsible for polarized vRNP trafficking.
| Project/Area Number |
22790438
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Virology
|
|---|
| Research Institution | Kitasato University |
|---|
Principal Investigator |
MOMOSE Fumitaka 北里大学, 大学院・感染制御科学府, 講師 (90332204)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Keywords | インフルエンザウイルス / 微小管 / 宿主因子 / モノクローナル抗体 / ライブセルイメージング / 低分子量GTP結合タンパク質 / リサイクリングエンドソーム |
|---|
| Research Abstract |
This study revealed that Rab11-positive recycling endosomes(RE) participate in the polarized trafficking of influenza A virus ribonucleoprotein complexes(vRNP) to the apical plasma membrane. The targeting of vRNP to the RE depends on the specific interaction between viral RNA dependent RNA polymerase on vRNP and GTP-bound active Rab11.This RE dependent apical transport of vRNP also requires class II Rab11 effector proteins such as Rab11-FIP3/4.
|
