2012 Fiscal Year Final Research Report
Identification and application of human brain genes that facilitate JC virus replication.
| Project/Area Number |
22790446
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Virology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
NAKAMICHI Kazuo 国立感染症研究所, ウイルス第一部, 主任研究官 (50348190)
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| Project Period (FY) |
2010 – 2012
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| Keywords | ウイルス / 脳 / 神経 / 脳神経疾患 |
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| Research Abstract |
JC virus is the causative agent of progressive multifocal leukoencephalopathy(PML), a fatal demyelinating disease in humans. Replicative efficacy of JCV in cultured cells is limited, which hampers in vitro studies including drug discovery. In this study, experimental systems were developed for the identification of human brain genes that facilitates JCV replication and for the establishment of JCV-permissive cell lines.
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[Journal Article] Sequential changes in the non-coding control region sequences of JC polyomaviruses from the cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy.2013
Author(s)
Nakamichi K, Kishida S, Tanaka K, Suganuma A, Sano Y, Sano H, Kanda T, Maeda N, Kira JI, Itoh A, Kato N, Tomimoto H, Kurane I, Lim CK, Mizusawa H, Saijo M
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Journal Title
Archives of Virology
Volume: 158
Pages: 639-650
DOI
Peer Reviewed
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