In vivo role of novel innate immune factors during viral infection

2011 Fiscal Year Final Research Report

• Project/Area Number: 22790450
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Hokkaido University
• Principal Investigator: OSHIUMI Hiroyuki 北海道大学, 大学院・医学研究科, 講師 (50379103)
• Project Period (FY): 2010 – 2011
• Keywords: 自然免疫 / ウイルス / インターフェロン / 核酸 / ユビキチン

Research Abstract

Innate immune response is essential for the protection against viral infection, such as novel flu or Hepatitis C virus. We have previously isolated a novel protein, Riplet. We constructed Riplet deficient mice and examined its phenotype. We found that Riplet is essential for type I interferon production, which possesses strong antiviral activity, in response to viral infection in vivo.

Research Products

• [Journal Article] Ubiquitin-mediated modulation of the cytoplasmic viral RNA sensor RIG-I (2012)
  • Author(s): Oshiumi H, Matsumoto M, and Seya T
  • Journal Title: J Biochem Volume: 151(1) Pages: 5-11
  • DOI: DOI:10.1093/jb/mvr111
  • Peer Reviewed
• [Journal Article] The toll-like receptor 3-mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice (2012)
  • Author(s): Abe Y, Fujii K, Nagata N, Takeuchi O, Akira S, Oshiumi H, Matsumoto M, Seya T, Koike S
  • Journal Title: J Virol Volume: Jan ; 86(1) Pages: 185-94
  • DOI: DOI:10.1128/JVI.05245-11
  • Peer Reviewed
• [Journal Article] The TLR3-TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection (2011)
  • Author(s): Oshiumi H, Okamoto M, Fujii K, Kawanishi, Matsumoto M, Koike S, and Seya T
  • Journal Title: J. Immunol Volume: 15 ; 187(10) Pages: 5320-7
  • DOI: DOI:10.1128/MCB.01368-10
  • Peer Reviewed
• [Journal Article] The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection (2010)
  • Author(s): Oshiumi H, Miyashita M, Inoue N, Okabe M, Matsumoto M, and Seya T
  • Journal Title: Cell Host & Microbe Volume: 8 Pages: 496-509
  • DOI: 10.1016/j.chom.2010.11.008
  • Peer Reviewed
• [Presentation] ウイルスによる自然免疫活性化とその抑制機構 (2012)
  • Author(s): 押海裕之
  • Organizer: 日本薬学会
  • Place of Presentation: 北海道大学(札幌市)
  • Year and Date: 2012-03-31
• [Presentation] The ubiquitin ligase Riplet is essential for RIG-I dependent type I interferon production in response to RNA virus infection (2011)
  • Author(s): 押海裕之
  • Organizer: 日本分子生物学会
  • Place of Presentation: バシフィコ横浜(神奈川)
  • Year and Date: 2011-12-14
• [Presentation] Regulatory mechanism of RIG-I by Riplet ubiquitin ligase (2011)
  • Author(s): 押海裕之
  • Organizer: 日本免疫学会
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2011-11-27
• [Remarks]
  • URL: http://www.hucc.hokudai.ac.jp/~e20536/