2011 Fiscal Year Final Research Report
Role of chemokine receptor CXCR3 on generation and maintenance of memory CD8 T cells
| Project/Area Number |
22790453
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KURACHI Makoto 東京大学, 大学院・医学系研究科, 助教 (00396722)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 免疫記憶 / CD8陽性T細胞 / CXCR3 / エフェクター分化 / 脾臓辺縁帯 |
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| Research Abstract |
It is not known how early lymphocyte distribution after infection has an impact on this process. We demonstrate that the chemokine receptor CXCR3 is involved in promoting CD8^+T cell commitment to an effector fate rather than a memory fate by regulating T cell recruitment to an antigen/inflammation site.
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