2011 Fiscal Year Final Research Report
Key roles of a nuclear IkappaB molecule, IkappaBNS, in the regulation of humoral immunity
| Project/Area Number |
22790457
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Niigata University |
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Principal Investigator |
TOUMA Maki 新潟大学, 自然科学系, 助教 (40542246)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 獲得免疫 |
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| Research Abstract |
IκBNS has been identified as a member of the IκB family of NF-κB inhibitors, which is recognized as a regulatory factor of innate immunity. In this study, I found that IκBNS KO B cells are deficient in proliferation, immunoglobulin production and plasma cell differentiation. These results suggest a previously unidentified role for IκBNS in humoral immune regulation.
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