Characterization of a novel STAT regulating factor in T cells

2011 Fiscal Year Final Research Report

• Project/Area Number: 22790463
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Osaka University
• Principal Investigator: KAMIMURA Daisuke 大阪大学, 大学院・生命機能研究科, 助教 (20391922)
• Project Period (FY): 2010 – 2011
• Keywords: T細胞 / ストレス応答 / 恒常性

Research Abstract

T cells play a central role in the adaptive immune system and there is a mechanism that maintains T cell number relatively constant in vivo. To gain a new insight into this homeostatic system, we used a mutagen to introduce point mutations in mice and screened them based on abnormal T cell phenotypes. We obtained a mutant with reduced naive T cell population(T-Red mice). The responsible gene is known to function in protein shuttling, but we found this gene is also involved in DNA repair pathway. Experimental data suggested that this new function contributes to the homeostasis of naive T cells in vivo.

Research Products

• [Journal Article] Regional Neural Activation Defines a Gateway for Autoreactive T Cells to Cross the Blood-Brain Barrier (2012)
  • Author(s): Arima Y., M. Harada, D. Kamimura, J-H. Park, F. Kawano, F. E. Yull, T. Kawamoto, Y. Iwakura, U. A. K. Betz, G. Marquez, T. S. Blackwell, Y. Ohira, T. Hirano, and M. Murakami
  • Journal Title: Cell Volume: 148 Pages: 447-457
  • Peer Reviewed
• [Journal Article] Local microbleeding facilitates IL-6. and IL-17. dependent arthritis in the absence of tissue antigen recognition by activated T cells (2011)
  • Author(s): Murakami, M., Y. Okuyama, H. Ogura, S. Asano, Y. Arima, M. Tsuruoka, M. Harada, M. Kanamoto, Y. Sawa, Y. Iwakura, K. Takatsu, D. Kamimura, T. Hirano
  • Journal Title: J. Exp. Med Volume: 208 Pages: 103-114
  • Peer Reviewed
• [Presentation] An ENU-mutant mouse, which increased a stress signaling in naive T cells (2011)
  • Author(s): Daisuke Kamimura Jing-jing Jiang, Shunji Mitani, Naoko Ueda, Mineko Tsuruoka, Takanori Hasegawa, Ikuko Miura, Shigeharu Wakana, Toshiyuki Fukada, and Toshio Hirano, and Masaaki Murakami
  • Organizer: 日本免疫学会
  • Place of Presentation: 千葉幕張メッセ
  • Year and Date: 2011-11-28
• [Presentation] Homeostatic proliferation of CD4+ T cells is involved in the pathogenesis of a mouse model of Omenn syndrome (2010)
  • Author(s): Kamimura D, Khiong K, Kitabayashi C, Ueda N, Sawa S, Sakamoto A, Kotzin BL, Rozzo SJ, Ishihara K, Verella-Garcia M, Kappler J, Marrack P, Hirano T, and Murakami M
  • Organizer: 第14回国際免疫学会
  • Place of Presentation: 神戸国際展示場
  • Year and Date: 20100822-27
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/molonc/www/index.html