2011 Fiscal Year Final Research Report
Roles of lymph node stromal cell network in T cell homeostasis
| Project/Area Number |
22790467
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TAKADA Kensuke 徳島大学, 疾患ゲノム研究センター, 講師 (40570073)
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| Research Collaborator |
TAKAHAMA Yousuke 徳島大学, 疾患ゲノム研究センター, 教授 (20183858)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 獲得免疫 / T細胞 |
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| Research Abstract |
As an initial step of a long-term project to understand the place of T cell homeostasis, we aimed to establish the classification of stromal cells constituting peripheral lymphoid tissues and to identify stromal cell subsets involved in the homeostasis of T cells. Stromal cells in the thymus and lymph nodes were analyzed for the expression of various molecular markers generally used for the classification of epithelial cells, blood endothelial cells, mesenchymal cells and mesenchymal stem cells. We found that alpha smooth muscle actin is potentially useful to classify fibroblastic reticular cells and perivascular cells which are thought to be important for T cell homeostasis.
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