2011 Fiscal Year Final Research Report
In vivo analysis of molecular mechanism for pre-TCR-mediatedβ-selection
| Project/Area Number |
22790470
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Kyushu University |
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Principal Investigator |
ISHIKAWA Eri 九州大学, 生体防御医学研究所, 助教 (20546478)
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| Project Period (FY) |
2010 – 2011
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| Keywords | リンパ球 / T細胞分化 |
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| Research Abstract |
The ligand for pre-TCR has not been identified for many years. To verifya model that we have recently proposed in vivo, we established mutant pre-TCRαchain(pTα) knock-in mice that lacks charged residues. From analysis of the mice, we first demonstrated that immature antigen receptor spontaneously induces signals through charged residues in pTαin vivo.
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