2013 Fiscal Year Final Research Report
Analysis for the role of follicular B helper T cells in the maintenance of germinal center B cells
| Project/Area Number |
22790479
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Kyoto University (2011-2013)
The Institute of Physical and Chemical Research (2010) |
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Principal Investigator |
SUZUKI Keiichiro 京都大学, 医学(系)研究科(研究院), 准教授 (90391995)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 濾胞性BヘルパーT細胞 / IgA / パイエル板 |
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| Research Abstract |
Majority of IgA+ B cells are induced in germinal centers (GCs) of Peyer's patches (PPs) depend on the function of follicular B helper T cells (TFH cells). TFH cells express high amount of the inhibitory receptor PD-1. The absence of PD-1 led to the expansion of PP TFH cells with different properties (over production of IFN-gamma and less production of IL-21) that caused disturbed repertoire of GC B cells. Thus, PD-1-/- mice had reduced affinity maturation of IgA producing plasma cells, and less binding capacity of secreted IgA on the surface of commensal bacteria in the gut, which led to the disturbed gut microbial communities in PD-1-/- mice. The dysbiosis induced over-activation of the systemic immune system with lymphocyte hyperplasia. Thus, TFH cells play critical roles to sustain GC B cells in PPs and to maintain the homeostasis of the immune system in our whole body.
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[Journal Article] Activation-induced cytidine deaminase expression in CD4+ T cells is associated with a unique IL-10-producing subset that increases with age2011
Author(s)
Qin H, Suzuki K, Nakata M, Chikuma S, Izumi N, Huong le T, Maruya M, Fagarasan S, Busslinger M, Honjo T, Nagaoka H
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Journal Title
PloS one
Volume: 6
Pages: e29141
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