2011 Fiscal Year Final Research Report
Identification of the role and molecular mechanism of Zn signal-mediated cytokine production
| Project/Area Number |
22790484
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
YAMASAKI Satoru 独立行政法人理化学研究所, サイトカイン制御研究グループ, 研究員 (30392161)
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| Project Period (FY) |
2010 – 2011
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| Keywords | サイトカイン産生 / 亜鉛ウエーブ / マスト細胞 / シグナル伝達 |
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| Research Abstract |
We have revealed the Zn wave, FcεRI-mediated intracellular Zn elevation upon antigen stimulation in mast cells. In this study, we further revealed that Zn-permeable voltage-gated L-type calcium channel(LTCC) is the channel for the Zn wave. In addition, LTCC-antagonist treatment suppressed the delayed-type hypersensitivity in mice, suggesting that LTCC might be the novel regulator for the cytokine production in mast cell.
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