2011 Fiscal Year Final Research Report
Cell therapy based on high-efficiency delivery of mesenchymal stem cells into the injured brain
| Project/Area Number |
22790508
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied pharmacology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 骨髄間葉系幹細胞 / 脳血管内皮細胞 / 血液脳関門 / リアルタイムイメージング / 細胞治療 / in vitro BBBモデル / 脳細胞傷害 / MAPキナーゼ |
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| Research Abstract |
The goal of this study is to achieve high-efficiency delivery of intravenously injected mesenchymal stem cells(MSCs) into the injured brain. We developed an in vitro culture system consisting of rat brain microvascular endothelial cells(BMECs) and bone marrow-derived MSCs. Live cell imaging using this system revealed that MSCs transmigrated across BMEC monolayers via a paracellular route. In addition, inhibition of MAP kinases affected transmigration of MSCs across BMEC monolayers.
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Research Products
(8 results)
