2011 Fiscal Year Final Research Report
X-ray crystallographic analysis of an ABC transporter
| Project/Area Number |
22790512
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied pharmacology
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| Research Institution | Kyoto University |
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Principal Investigator |
KODAN Atsushi 京都大学, 物質.細胞統合システム拠点, 研究員 (80360543)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 生体分子 / 蛋白質 / 薬学 / 癌 |
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| Research Abstract |
Understanding the mechanism of action of ABC proteins and developing new therapeutic strategies that target ABC proteins would be considerably accelerated with the three-dimensional structures. Crystal structure of an exporter-type ABC transporter from a unicellular eukaryote was determined by the multiwavelength anomalous dispersion(MAD) method using the X-ray diffraction data measured at SPring-8. The resolution obtained in this study is best among those of eukaryotic ABC proteins ever reported to date.
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