2012 Fiscal Year Final Research Report
The relationship between angiotensin II and megalin in proteinuria
| Project/Area Number |
22790514
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied pharmacology
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| Research Institution | Osaka Ohtani University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | メガリン / タンパク尿 / アンジオテンシンII |
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| Research Abstract |
We examined the improvement of proteinuria in the 5/6 nephrectomy model (Nx) and the effect of an association between an AT-1 receptor blocker, losartan (L), and megalin. The proteinuria insignificant decreased to Nx model rat treated with L as compared with Nx model rats. We demonstrated that megalin reduced in Nx model rat kidney by immunohistochemistry using anti-megalin antibody. On the other hands, expression of megalin recovered to sham level in Nx model rat treated with L. Megalin is a multiligand endocytotic receptor involving in the reabsorption of low molecular weight proteins in renal proximal tubule. Accordingly, this data suggest that rescue of megalin expression were contributed to improvement of proteinuria.
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[Journal Article] Sodium-coupled neutral amino acid transporter 4 functions as a regulator of protein synthesis during liver development2013
Author(s)
Kondou H, Kawai M, Tachikawa K, Kimoto A,Yamagata M, Koinuma T, Yamazaki M,Nakayama M, Mushiake S, Ozono K, Michigami T.
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