2011 Fiscal Year Final Research Report
Establishment of the Enhancement Effect of 2-Arachidonylglycerol on Antimicrobial Peptide Induction
| Project/Area Number |
22790516
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied pharmacology
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| Research Institution | Fukuoka University |
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Principal Investigator |
IRIE Keiichi 福岡大学, 加齢脳科学研究所, 研究員 (50509669)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 2-アラキドノイルグリセロール / 抗菌ペプチド / カンナビノイド |
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| Research Abstract |
Antimicrobial peptides(AMPs) are secreted from intestinal epithelium cell as the starting point for infection, contribute to innate immunity in the intestinal tract. We investigated that the 2-arachidonylglycerol(2-AG) secretes AMPs and that injection of 2-AG suppresses infection of pathogenic microorganism. The present study showed that 2-AG secreted the AMPs from Caco-2 cells. Furthermore, 2-AG suppressed the total number of E. coli marker during 6-hour period. Taken together, we found that 2-AG might suppress against pathogenic microorganism infection by secreting AMPs from intestinal epithelium cells.
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Research Products
(6 results)
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[Presentation] 2-Arachidonylglycerol protects against infection by secretion of antimicrobial peptides from the intestinal tract2011
Author(s)
Saori Uyeda, Keiichi Irie, Takahiro Okuno, Shodai Tsuruda, Mari Ioki, Yukie Tamura, Tomomitsu Satho, Kenichi Miahima, Yukihiko Nakashima, Nobuhiro Kashige, Fumio Miake
Organizer
International Union of Microbiological Societies 2011 Congress
Place of Presentation
北海道
Year and Date
2011-09-07
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