2012 Fiscal Year Final Research Report
New drug sensitivity test for leukemia mimicking bone marrow microenvironment in hypoxia
| Project/Area Number |
22790523
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Laboratory medicine
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
ITOH Mai 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (70415545)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 臨床血液学 / 白血病 / 低酸素 |
|---|
| Research Abstract |
For treatment of leukemia, it is necessary to assess antileukemia agent by precise drug sensitivity test. We assumed that cell culture system in hypoxia mimicking bone marrow microenvironment is useful for assess the effect than the system in normoxia. In this study, we found that hypoxia culture system upregurated HIF protein expression as well as affected Notch, NF-kB, and mTOR signaling in leukemia stem cells. We established a basis for a new drug sensitivity test in hypoxia.
|
