2012 Fiscal Year Final Research Report
Diagnostic value of immunohistochemical expression of IMP3 in transpapillary biliary forceps biopsy samples of extrahepatic bile duct carcinoma
| Project/Area Number |
22790525
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 経乳頭的胆管生検 / ERCP / 胆管癌 / 胆道癌 / IMP3 / S100P / 免疫染色 |
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| Research Abstract |
The objective of this study is to clarify the diagnostic and prognostic value of immunohistochemical expression of S100P andIMP3 in transpapillary biliary forceps biopsy (TBFB) samples. The TBFB samples were collected from 80 patients (extrahepatic bile duct carcinoma, 68 patients; benign, 12 patients), retrospectively. The sensitivity, specificity and accuracy achieved 89.7 %, 91.7 % and 90.0 %, respectively, when using positive staining for IMP3and/or positive histology as a maker of malignancy. While univariate (P= 0.033) and multivariate (P= 0.039) analysis revealed that S100P-positive extrahepatic bile duct carcinoma patients showed significantly shorter survival.
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Research Products
(4 results)
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[Journal Article] Diagnostic and prognostic value of immunohistochemical expression of S100P and IMP3 in transpapillary biliary forceps biopsy samples of extrahepatic bile duct carcinom2013
Author(s)
Kawashima H, Itoh A, Ohno E, Miyahara R, Ohmiya N, Tanaka T, Shimoyama Y,Nakamura S, bata T, Nagino M, Goto H, Hirooka Y
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Journal Title
J Hepatobiliary Pancreat Sci
Volume: 20
Pages: 441-447
Peer Reviewed
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