Proteomic analysis of secreted protein of ovarian clear cell adenocarcinoma for therapeutic and diagnostic applications.

2011 Fiscal Year Final Research Report

• Project/Area Number: 22790530
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Laboratory medicine
• Research Institution: Yokohama City University
• Principal Investigator: ARAKAWA Noriaki 横浜市立大学, 大学院生命ナノシステム科学研究科, 助教 (60398394)
• Project Period (FY): 2009 – 2011
• Keywords: プロテオミクス / 卵巣癌 / 明細胞腺癌 / 腫瘍マーカー / 分泌タンパク質

Outline of Final Research Achievements

Of all of the epithelial ovarian cancers, clear cell adenocarcinoma (CCA) has the worst prognosis. In addition, level of CA125, a conventional marker for ovarian cancer, is relatively low and frequently negative in patients with CCA. Therefore, development of new biomarker is needed to improve diagnosis of CCA. In this study, we analyzed secreted proteins in conditioned media from CCA-derived cell lines by a proteomic approach, and identified a potential biomarker candidate with clinical utilities. Serum level of the identified protein was significantly elevated in CCA patients.

Free Research Field

医歯薬学