2012 Fiscal Year Final Research Report
Elucidation of CD109 function and its tumor promotion using transgenic mice overexpressing CD109
| Project/Area Number |
22790532
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory medicine
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| Research Institution | Chubu University |
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Principal Investigator |
SOBUE Sayaka 中部大学, 臨床検査技術教育・実習センター, 助教 (50513347)
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| Project Period (FY) |
2010 – 2012
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| Keywords | CD109 / トランスジェニックマウス |
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| Research Abstract |
In this study, I first generated a transgenic mouse overexpressing CD109 under control of CAG promoter and investigated its molecular function using the transgenic mouse. I observed elevated serum-concentration of soluble form of CD109. Thereafter I found tumor development in one-third of the transgenic mice around the age of one year. Its molecular mechanisms remain under study. I next investigated why CD109 is up-regulated during carcinogenesis in several carcinomas by promoter analysis of CD109. I finally demonstrated that CD109 expression is up-regulated in subsets of carcinomas through Egr1 induction during their carcinogenesis.
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[Journal Article] Sphingosine kinase 1 expression is downregulated during differentiation of Friend cells due to decreased c-MYB.2013
Author(s)
Mizutani N, Kobayashi M, Sobue S, Ichihara M, Ito H, Tanaka K, Iwaki S, Fujii S, Ito Y, Tamiya-Koizumi K, Takagi A, Kojima T, Naoe T, Suzuki M, Nakamura M, Banno Y, Nozawa Y, Murate T.
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Journal Title
Biochim Biophys Acta.
Volume: 1833
Pages: 1006-1016
Peer Reviewed
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[Journal Article] Epidermal Hyperplasia and AppendageAbnormalities in Mice Lacking CD109.2012
Author(s)
Mii S, Murakumo Y, Asai N, Jijiwa M, Hagiwara S, Kato T, Asai M, Enomoto A, Ushida K, Sobue S, Ichihara M, Takahashi M
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Journal Title
Am J Pathol.
Volume: 181
Pages: 1180-1189
Peer Reviewed
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[Journal Article] Transcriptional regulation of neutral sphingomyelinase 2 in all-trans retinoic acid-treated human breast cancer cell line2012
Author(s)
Ito H, Tanaka K, Hagiwara K, Kobayashi M, Hoshikawa A, Mizutani N, Takagi A, Kojima T, Sobue S, Ichihara M, Suzuki M, Tamiya-Koizumi K, Nakamura M, Banno Y, Nozawa Y, Murate T.
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Journal Title
MCF-7. J Biochem.
Volume: 151
Pages: 599-610
Peer Reviewed
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[Journal Article] Sphingosine Kinase 1/S1P PathwayInvolvement in the GDNF-Induced GAP43Transcription.2011
Author(s)
Murakami M, Ito H, Hagiwara K, Kobayashi M, Hoshikawa A, Takagi A, Kojima T, Tamiya-Koizumi K, Sobue S, Ichihara M, Suzuki M, Banno Y, Nozawa Y, Murate T.
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Journal Title
J Cell Biochem.
Volume: 112
Pages: 3449-3458
Peer Reviewed
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[Journal Article] Heterogeneous sphingosine-1-phosphate lyase gene expression and its regulatory mechanism in human lung cancer cell lines.2011
Author(s)
Ito H, Yoshida K, Murakami M, Hagiwara K, Sasaki N, Kobayashi M, Takagi A, Kojima T, Sobue S, Suzuki M, Tamiya-Koizumi K, Nakamura M, Banno Y, Nozawa Y, Murate T.
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Journal Title
Biochim Biophys Acta.
Volume: 1811
Pages: 119-128
Peer Reviewed
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