2011 Fiscal Year Final Research Report
Discovery of biomarkers for early colon cancer using a phospho-proteomic approach
| Project/Area Number |
22790539
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory medicine
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| Research Institution | 独立行政法人医薬基盤研究所 |
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Principal Investigator |
KUGA Takahisa 独立行政法人医薬基盤研究所, プロテオームリサーチプロジェクト, 研究員 (20551857)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 腫瘍検査学 |
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| Research Abstract |
The profile of protein phosphorylation in colon malignant tumor tissues were compared with those in colon benign tumor and non-tumor tissues using a phospho-proteomic technique(Phospho-iTRAQ). Phosphorylation levels at more than 200 phosphorylation sites were altered in the malignant tumor tissues, suggesting that these alterations are candidates for colon cancer. To validate these candidates, a phospho-SI-SRM technique was developed. Using these proteomic techniques and bioinformatics, I identified candidate biomarkers for colon cancer and signaling proteins involved in colon cancer.
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[Presentation] Global phosphorylation and ubiquitination dynamics in DNA-damage response network2011
Author(s)
J. Adachi, R. Narumi, S. Sano, T. Kuga, T. Shiromizu, M. Matsumoto, K. Nakayama, M. Ikura, T. Ikura, M. Takata, T. Tomonaga
Organizer
HUPO2011
Place of Presentation
Geneva, Switzerland
Year and Date
20110904-07
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