2011 Fiscal Year Final Research Report
Roles of HIF-1α on wound healing of airway epithelial cells
| Project/Area Number |
22790545
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Waseda University (2011)
Osaka University (2010) |
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Principal Investigator |
SHIRATO Ken 早稲田大学, 人間科学学術院, 助手 (60559384)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 気道上皮 / 創傷治癒 / Hypoxia-inducible factor(HIF)-1α / 細胞生理学 / 分子生物学 |
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| Research Abstract |
When airway epithelial cells were stimulated by scratch wound, hypoxia-inducible factor(HIF)-1α is accumulated into the nucleus of the cells located at the wound margin. HIF-1α deprivation promoted wound healing of airway epithelial cells. By contrast, HIF-1α inducer suppressed wound healing of the cells, and this effect was attenuated by HIF-1α deprivation. These results suggest that scratch wound-induced HIF-1α is a negative regulator for wound healing of airway epithelial cells.
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