2012 Fiscal Year Final Research Report
Relationship between environmental factors and childhood allergies
| Project/Area Number |
22790546
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | University of Occupational and Environmental Health, Japan (2011-2012)
Kumamoto University (2010) |
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Principal Investigator |
TSUJI Mayumi 産業医科大学, 医学部, 講師 (40457601)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 母子保健 / アレルギー・喘息 / 社会医学 / 分子疫学 |
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| Research Abstract |
Study purpose is to search the biomarkers indicating relations of the childhood allergies and environmental factors.
[Material and Methods] We did questionnaire survey and the measurement of the specific IgE levels, serum level of PCBs and mRNA by using the children's blood.
[Result] We extracted 30 preschool children (healthy children 15, asthmatic children 15) from subjects (N=200). (1) IL-8 mRNA expression was high in the children who were asthma and had high level of PCB concentration. (2) IL-22mRNA expression was high in the children who were IgE positive and had high level of PCB concentration.
[Conclusion] Our results suggested that the possibility that IL-8 and IL -22 were useful biomarkers for environmental exposure in allergic children.
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