2011 Fiscal Year Final Research Report
Investigation of immunological parameters related with malignant mesothelioma, based on study of asbestos-caused impairment in cytotoxicity of NK cells
| Project/Area Number |
22790550
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | 産業衛生 |
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| Research Abstract |
The in vitro study showed that asbestos exposure caused the decreases in production of IL-12 by monocyte-lineage cells and IFN-γ and IL-17A by Th cells, related with low NKp46 on NK cells. The six-seventh patients with mesothelioma showed a higher value of the formula, calculated from multiple linear regression analysis of cytokine levels in blood, than healthy or pleural plaque-positive people, suggesting that such formula might be a new marker for mesothelioma.
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Research Products
(37 results)
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[Journal Article] Asbestos-induced cellular and molecular alteration of immunocompetent cells and the relationship with chronic inflammation and carcinogenesis2012
Author(s)
Matsuzaki H, Maeda M, Lee S, Nishimura Y, Kumagai-Takei N, Hayashi H, Yamamoto S, Hatayama T, Kojima Y, Tabata R, Kishimoto T, Hiratsuka J, Otauki T.
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Journal Title
J Biomed Biotechnol
Volume: Volume 2012
Pages: 492608
DOI
Peer Reviewed
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[Journal Article] Reduction of CXCR3 in an in vitro model of continuous asbestos exposure on a human T-cell line, MT-22011
Author(s)
Maeda M, Nishimura Y, Hayashi H, Kumagai N, Chen Y, Murakami S, Miura Y, Hiratsuka J, Kishimoto T, Otsuki T.
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Journal Title
Am J Resp Cell Mol Biol
Volume: 45(3)
Pages: 470-9
Peer Reviewed
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[Journal Article] 科学技術振興調整費「アスベスト関連疾患への総括的取り組み」班研究:成果報告-班研究の概要と登録事業,中皮腫細胞特性ならびにアスベストの免疫影響について-2011
Author(s)
大槻剛巳, 中野孝司, 長谷川誠紀, 岡田守人, 辻村亨, 関戸好孝, 豊國伸哉, 西本寛, 福岡和也, 田中文啓, 熊谷直子, 前田恵, 松崎秀紀, 李順姫, 西村泰光
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Journal Title
日本衛生学雑誌
Volume: 66(3)
Pages: 543-552
Peer Reviewed
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[Journal Article] Resistance to asbestos-induced apoptosis with continuous exposure to crocidolite on a human T cell
Author(s)
Meada M, Yamamoto S, Chen Y, Kumagai-Takei N, Hayashi H, Matsuzaki H, Lee S, Hatayama T, Miyahara N, Katoh M, Hiratsuka J-i, Nishimura Y, Otsuki T.
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Journal Title
Sci Tot Environ
Volume: (in press)
Peer Reviewed
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