2011 Fiscal Year Final Research Report
The association between blood polyphenol levels and DNA methylation levels in gastric mucosa
| Project/Area Number |
22790554
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East |
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Principal Investigator |
SHIMAZU Taichi 独立行政法人国立がん研究センター, がん予防・検診研究センター, 研究員 (00466202)
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| Project Period (FY) |
2010 – 2011
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| Keywords | エピジェネティクス / 胃がん / 食事 / 疫学 |
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| Research Abstract |
We conducted a cross-sectional study to investigate the association between blood polyphenol levels and DNA methylation levels in gastric mucosa of participants(n=300) who underwent upper gastrointestinal endoscopy as part of the cancer screening program. We found no association between serum polyohenol levels(daidzein, genistein,(-)-epicatechin,(-)-epicatechin-3-gallate,(-)-epigallocatechin, and(-)-epigallocatechin-3-gallate) and DNA methylation levels of three markers which were associated with gastric cancer risk.
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