A prospective study on assessment of individuals with metabolic syndrome at the high risk for cardiovascular disease all-cause death in general Japanese population

2011 Fiscal Year Final Research Report

• Project/Area Number: 22790563
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Public health/Health science
• Research Institution: Sapporo Medical University
• Principal Investigator: OHNISHI Hirofumi 札幌医科大学, 医学部, 講師 (20359996)
• Project Period (FY): 2010 – 2011
• Keywords: メタボリックシンドローム / 肥満 / 予防医学 / 特定健診・特定保健指導

Research Abstract

We investigated the effects of the combination of metabolic syndrome and high-sensitivity C-reactive protein(hsCRP) level or urinary 8-hydroxydeoxyguanosine(OHdG) on cardiovascular disease and all-cause death in general Japanese population. In the cross sectional study, combination of MetS and hsCRP was a good indicator for prevalence of cardiovascular disease. In the prospective study, combination of MetS and hsCRP or 8-OHdG tended to be predictors for all-cause death but we could not find statistically significant relations. The combination of MetS and hsCRP or 8-OHdG may become a good predictor for cardiovascular disease and all-cause death and further follow-up of those participants may be needed to assess these relations.

Research Products

• [Journal Article] DeFronzo insulin sensitivity index is a better predictor than HOMA-IR of hypertension in Japanese : the Tanno-Sobetsu study (2011)
  • Author(s): Furugen M, Saitoh S, Ohnishi H, Akasaka H, Mitsumata K, Chiba M, Furukawa T, Miyazaki Y, Shimamoto K, Miura T. Matsuda
  • Journal Title: J Hum Hypertens
  • DOI: DOI:10.1038/jhh.2011.23
  • Peer Reviewed
• [Journal Article] 地域一般住民高齢者・非高齢者における腹部肥満の糖尿病発症リスクに関する検討 (2011)
  • Author(s): 藤井瑞恵, 大西浩文, 斎藤重幸, 森満, 島本和明
  • Journal Title: 日老医誌 Volume: 48 Pages: 71-77
  • URL: https://www.jstage.jst.go.jp/article/geriatrics/48/1/48_1_71/_pdf
  • Peer Reviewed
• [Journal Article] Associations of metabolic factors, especially serum retinol-binding protein 4(RBP4), with blood pressure in Japanese-the Tanno and Sobetsu study- (2011)
  • Author(s): Chiba M, Saitoh S, Ohnishi H, Akasaka H, Mitsumata K, Furukawa T and Shimamoto K
  • Journal Title: Endocrine Journal Volume: 57 Pages: 811-817
  • URL: https://www.jstage.jst.go.jp/article/endocrj/57/9/57_K10E-054/_pdf
  • Peer Reviewed
• [Presentation] 地域一般住民におけるITを用いた遠隔在宅血圧管理サポートシステムの試み～壮瞥町在宅血圧管理プロジェクトからの報告～ (2011)
  • Author(s): 大西浩文, 斎藤重幸, 赤坂憲, 三俣兼人, 古川哲章, 森満, 三浦哲嗣, 島本和明
  • Organizer: 第34回日本高血圧学会総会
  • Place of Presentation: 宇都宮
  • Year and Date: 20111020-22
• [Presentation] 地域一般住民におけるALT、γ-GTPの組み合わせによる新規糖尿病発症予測に関する検討-端野・壮瞥町研究より- (2011)
  • Author(s): 大西浩文, 斎藤重幸, 赤坂憲, 三俣兼人, 古川哲章, 森満, 三浦哲嗣
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌
  • Year and Date: 20110519-21
• [Presentation] 地域一般住民における空腹時血糖高値の高血圧罹患リスクに関する検討-端野・壮瞥町研究より- (2010)
  • Author(s): 大西浩文、斎藤重幸、赤坂憲、三俣兼人、千葉瑞恵、古堅真、古川哲章、森満、島本和明
  • Organizer: 第33回日本高血圧学会総会
  • Place of Presentation: 福岡
  • Year and Date: 20101015-17
• [Presentation] (2010)
  • Author(s): Hirofumi Ohnishi, Shigeyuki Saitoh, Hiroshi Akasaka, Kaneto Mitsumata, Mizue Chiba, Makoto Furugen, Tetsuaki Furukawa, Mitsuru Mori, Kazuaki Shimamoto
  • Organizer: Vancouver Hypertension 2010
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 20100926-30
• [Presentation] 地域一般住民高齢者・非高齢者における正常高値血糖からの糖尿病発症リスクに関する検討-端野・壮瞥町研究より- (2010)
  • Author(s): 大西浩文、斎藤重幸、赤坂憲、三俣兼人、千葉瑞恵、古堅真、古川哲章、森満、島本和明
  • Organizer: 第52回日本老年医学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 20100624-26
• [Presentation] 地域一般住民における糖尿病と喫煙のがん死亡に与える影響-端野・壮瞥町研究より- (2010)
  • Author(s): 大西浩文、斎藤重幸、赤坂憲、三俣兼人、千葉瑞恵、古堅真、古川哲章、森満、島本和明
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山
  • Year and Date: 20100527-29
• [Presentation] Plasma B-type natriuretic peptide levels and the risk for cardiovascular events in rural communities in Japan-The Tanno and Sobetsu Study- (2010)
  • Author(s): Hirofumi Ohnishi, Shigeyuki Saitoh, Hiroshi Akasaka, Kaneto Mitsumata, Mizue Chiba, Makoto Furugen, Tetsuaki Furukawa, Mitsuru Mori, Kazuaki Shimamoto
  • Organizer: 第74回日本循環器学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 20100305-07