2011 Fiscal Year Final Research Report
Analysis of cellular toxicity by treatment with norephedrine.
| Project/Area Number |
22790594
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Legal medicine
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
FUNAKOSHI Takeshi 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (40444715)
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| Project Period (FY) |
2010 – 2011
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| Keywords | ノルエフェドリン / オートファジー / 覚せい剤原料 |
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| Research Abstract |
Norephedrine was widly used as over-the-counter cough and cold medicin and law-evading drug. In this study, we considered effects of norephedrine induced neuronal cell injury. Norephedrine induced vacuolation rapidly and cell viability was reduced. Norephedrine induced autophagy and then cell death with both lysosomal disfunction and disruption of autophagic flux.
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