2012 Fiscal Year Final Research Report
Histopathological evaluation of ante-mortem general condition using immunohistochemically-stained lung
| Project/Area Number |
22790595
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Legal medicine
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| Research Institution | Mie University |
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Principal Investigator |
INOUE Hiromasa 三重大学, 大学院・医学系研究科, 准教授 (50363338)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 法医病理学 |
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| Research Abstract |
In acute lung injury (ALI) induced by heat exposure and/or venous injection of oleic acid, Il-1β, IL-6, TNF-α, MIP2 and IL-10, which are related to inflammatory reaction, were increased at short times. In addition, IL-1β expressions of mRNA and protein were synergistically increased by venous injection of oleic acid after heat exposure, which suggested that prognosis of ALI induced by pulmonary fat embolization would be deteriorated by the severity of precedent injuries and/or diseases which can induce to pulmonary fat embolization. Moreover, mRNA expressions of vegfa, tgfb1 and gm-csf were also induced at short times after the insults, and TGF-β1 was significantly expressed as well as mRNA. These proteins would be available for evaluating general condition in forensic autopsy cases where the individual suddenly dies.
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Research Products
(6 results)
