2011 Fiscal Year Final Research Report
Epigenetics of mechanism of augmentation for traumatic brain edema under ethanol consumption : role of microRNA
| Project/Area Number |
22790601
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Legal medicine
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Keywords | アルコール医学 / 頭部外傷 / アクアポリン4 |
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| Research Abstract |
It has been well known that ethanol has the detrimental effect on traumatic brain injury. We previously reported that ethanol augments brain edema after brain contusion. In this study, to elucidate the mechanism of brain edema augmentation by ethanol, rat traumatic brain injury model and astrocyte culture experimnents were performed. The increase of aquaporin-4, an water channel, and the decrease of sodium ion concentration had the effects on the augmentation of brain edema under ethanol consumption. These findings suggest that the inhibitor of aquaporin-4 and hyponatremia may be a new treatment of brain edema aftet traumatic brain injury.
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