2011 Fiscal Year Final Research Report
A study for establishment of diagnostic markers in sudden infant death syndrome by imaging mass spectrometry.
| Project/Area Number |
22790603
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Legal medicine
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| Research Institution | Osaka Medical College |
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Principal Investigator |
SATO Takako 大阪医科大学, 医学部, 助教 (10530420)
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| Project Period (FY) |
2010 – 2011
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| Keywords | 法医病理学 |
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| Research Abstract |
Sudden infant death syndrome(SIDS) is one of the major causes of infant mortality. However, the causes of SIDS are still unknown. It is pointed out that developmental delays in the central cardiovascular and respiratory regulation may be involved. Our research intended to examine whether myelin structural proteins, such as myelin basic protein(MBP), are useful as diagnostic markers of SIDS by direct analysis of brain tissue using imaging mass spectrometry. Paraffin-embedded sections seemed to be ideal because the cases have been accumulated, but they were found to be unsuitable for the analysis. Though frozen sections are suitable, the number of cases is insufficient. It is necessary to accumulate the number of samples for further study.
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