2012 Fiscal Year Final Research Report
The effect of kakkonto in allergic immune response mediated by dendritic cells on intestinal mucosal immune system
| Project/Area Number |
22790616
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | University of Toyama |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 東洋医学 / 葛根湯 / 腸管粘膜免疫 / 食物アレルギー / 制御性細胞 / 樹状細胞 |
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| Research Abstract |
Kakkonto, a traditional Japanese herbal medicine, suppressed the occurrence of allergic symptoms in an FA mouse model. Furthermore, Puerariae radix extract and several isoflavones suppressed the occurrence of allergic symptoms in an FA mouse model. The proportion of CD4+Foxp3+regulatory T cells in lamina propria was significantly increased bykakkonto treatment and isoflavones treatment as compared with FA mouse model. Our data suggest that CD4+Foxp3+regulatory T cells induced by kakkonto and isoflavones had suppressive effects on intestinal mucosal immunity in FA mice.
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